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Rechallenge descriptive

Source: R/desc_rch.R
desc_rch.Rd

[Stable] Computes counts of rechallenge cases, over a set of adr and drug pairs.

Usage

desc_rch(.data, drug_s = "drug1", adr_s = "adr1")

Arguments

.data

A link data.table. See link_.

drug_s

A character string. The name of the drug column. Drug columns can be created with add_drug.

adr_s

A character string. The name of the adr column. Adr columns can be created with add_adr.

Value

A data.table with one row per drug-adr pair

  • drug_s and adr_s, same as input.

  • Counts of overall, rch, inf, and rec cases (see details).

Details

Counts are provided at the case level (not the drug-adr pair level). Description span from number of rechallenge cases to informative rechallenge cases (those cases where the outcome is known). You will need a link data.table, see link_, on which you have added drugs and adrs with add_drug() and add_adr(). Terminology

  • Overall as opposed to rch for rechallenged (rch + no_rch = overall).

  • Among rch, inf (informative) as opposed to non_inf (inf + non_inf = rch)

  • Among inf, rec (recurring) as opposed to non_rec (rec + non_rec = inf)

See also

link_, add_drug(), add_adr(), desc_dch(), desc_tto()

Examples

link_ <-
  link_ |>
  add_drug(
    d_code = ex_$d_groups_drecno,
    drug_data = drug_
  ) |>
  add_adr(
    a_code = ex_$a_llt,
    adr_data = adr_
  )
#> ℹ `.data` detected as `link` table.
#> ℹ `.data` detected as `link` table.

desc_rch(.data = link_,
         drug_s = "pd1",
         adr_s = "a_colitis")
#>    drug_s     adr_s n_overall n_rch n_inf n_rec
#>    <char>    <char>     <int> <int> <int> <int>
#> 1:    pd1 a_colitis        81    54    44    16

# You can vectorize over drugs and adrs

desc_rch(.data = link_,
         adr_s = c("a_colitis", "a_pneumonitis"),
         drug_s = c("pd1", "pdl1")
         )
#>    drug_s         adr_s n_overall n_rch n_inf n_rec
#>    <char>        <char>     <int> <int> <int> <int>
#> 1:    pd1     a_colitis        81    54    44    16
#> 2:   pdl1     a_colitis        16     7     0     0
#> 3:    pd1 a_pneumonitis        96    66    55    12
#> 4:   pdl1 a_pneumonitis         6     3     0     0